Malignant tumors

Thyroid primary mucoepidermoid carcinoma is a malignant tumor classified as a salivary gland-type carcinoma of the thyroid. This type of tumor is extremely rare, with only a dozen cases reported to date, and has a high incidence in females. Due to its rarity, misdiagnosis can occur in clinical practice.

7p vihizuzen 26-05-2025 1 1   Download

To learn about some clinical and histological characteristics of bladder cancer, as well as investigate about some factors related to muscle-invasion in newly diagnosed bladder cancer. Subject and method: A descriptive retrospective study was conducted on 416 patients with newly diagnosed bladder cancer who underwent transurethral resection of bladder tumor within 6 years from 2018 to 2023 at 108 Military Central Hospital.

6p vihizuzen 26-05-2025 1 1   Download

Colorectal cancer (CRC) is a malignant tumor arising from the inner lining of the colon or rectum and is the third most common cancer and the third leading cause of cancer-related deaths in the United States. This article reports two cases of heavily pretreated metastatic CRC (mCRC) with HER2 overexpression who achieved a remarkable clinical response to trastuzumab plus pertuzumab.

7p vimitsuki 06-05-2025 1 1   Download

The aim of this study is to (1) Describe the ultrasound characteristics of ovarian tumors according to the O-RADS classification. (2) Investigate the signs predicting malignancy in the O-RADS 3, 4, and 5 categories.

7p viengfa 23-10-2024 2 1   Download

Breast cancer is the most common malignancy and the second leading cause of death in women. While tamoxifen (TAM) remains to be a first-line agent for prevention and treatment of estrogenreceptor (ER) positive breast tumors, TAM resistance represents one of the biggest clinical challenges in breast cancer therapy.

9p vihyuga 04-03-2025 3 1   Download

The aim of this study is to (1) Describe the ultrasound characteristics of ovarian tumors according to the O-RADS classification. (2) Investigate the signs predicting malignancy in the O-RADS 3, 4, and 5 categories.

7p viharuno 03-01-2025 3 2   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

9p caothientrangnguyen 09-05-2020 20 3   Download

Malignant insulinoma is an extremely uncommon tumor that is usually accompanied by severe hypoglycemia that is difficult to manage. At this time, the long-term effect of 177Lu-DOTATATE (lutetium [Lu-177]- DOTA-Tyr3-octreotate) on this tumor is not well known.

4p caothientrangnguyen 09-05-2020 21 1   Download

Amplification of N-myc oncogene is a frequent event in advanced stages of human neuroblastoma and correlates with poor prognosis and enhanced neovascularization. Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies, which is modulated by tumor suppressors and oncogenes. We have addressed the possibility that N-myc oncogene might regulate angiogenesis in neuroblastoma. Here, we report that experimental N-Myc overexpression results in down-regulation of leukemia inhibitory factor (LIF), a modulator of endothelial cell proliferation....

10p system191 01-06-2013 37 4   Download

Glutamine is an essential amino acid in cancer cells and is required for the growth of many other cell types. Glutami-nase activity is positively correlated with malignancy in tumours andwith growth rate in normal cells. In the present work, Ehrlich ascites tumour cells, and their derivative, 0.28AS-2 cells, expressing antisense glutaminase mRNA, were assayed for apoptosis induced by methotrexate and hydrogen peroxide. It is shown that Ehrlich ascites tumour cells, expressing antisense mRNA for glutaminase, contain lower levels of glutathione than normal ascites cells. In addition, 0.

9p awards 05-04-2013 48 4   Download

Owing to theuseof porphyrins inphotodynamic therapy for the treatment of malignant tumors, and the preferential interaction of lectins with tumor cells, studies on lectin– porphyrin interactionareof significant interest. In this study, the interaction of several free-base and metalloporphyrins withMomordica charantia(bitter gourd) lectin (MCL) was investigated by absorption spectroscopy. Difference absorp-tion spectra revealed that significant changes occur in the Soret band region of the porphyrins on binding to MCL....

0p awards 05-04-2013 58 3   Download

The creatine⁄creatine kinase system decreases drastically in sarcoma. In the present study, an investigation of catalytic activities, western blot and mRNA expression unambiguously demonstrates the prominent expression of the creatine-synthesizing enzymesl-arginine:glycine amidinotransferase andN-guanidinoacetate methyltransferase in sarcoma, Ehrlich ascites carci-noma and Sarcoma 180 cells, whereas both enzymes were virtually unde-tectable in normal muscle.

11p vinaphone15 28-02-2013 34 2   Download

Aberrant differentiation is a characteristic feature of neoplastic transforma-tion, while hypoxia in solid tumors is believed to be linked to aggressive behavior and poor prognosis. However, the possible relationship between hypoxia and differentiation in malignancies remains poorly defined.

14p vinaphone15 27-02-2013 38 2   Download

Papillomaviruses are epitheliotropic non-enveloped double-stranded DNA viruses, whose replication is strictly dependent on the terminally differenti-ating tissue of the epidermis. They induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carci-noma). Prior to entry into basal cells, virions attach to heparan sulfate moieties of the basement membrane.

11p viettel02 20-02-2013 40 3   Download

The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors.

20p viettel02 19-02-2013 54 4   Download

The function of the epidermal growth factor receptor (EGFR) is dysregu-lated in various types of malignancy as a result of gene amplification, mutations, or abnormally increased ligand production. Therefore, the tyro-sine kinase activity of the EGFR is a promising therapeutic target.

11p mobifone23 18-01-2013 45 4   Download

It is becoming increasingly clear that signals generated in tumor microenvi-ronments are crucial to tumor cell behavior, such as survival, progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites and to localize to distant organs.

15p cosis54 05-01-2013 37 5   Download

Human chromosome 7 ORF 24 (C7orf24) has been identified as a tumor-related protein, and shown to be ac-glutamyl cyclotransferase. In the cur-rent study, we characterized the promoter region of the human C7orf24 gene to explore the transcriptional regulation of the gene.

12p cosis54 09-12-2012 41 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances

9p dauphong6 05-01-2012 49 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Abstract Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still poor.

10p dauphong4 03-01-2012 67 5   Download